A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice.

A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice† †Electronic supplementary information (ESI) available: Experimental details, photophysical data, some fluorescence imaging figures, average fluorescence intensity figures and in vivo imaging. See DOI: 10.1039/c6sc05646f Click here for additional data file.

NBD-based colorimetric and fluorescent turn-on probes for hydrogen sulfide.

Hydrogen sulfide (H2S) is an important endogenous signalling molecule and also an important environmental target for detection. New reaction-based colorimetric and fluorescent turn-on probes based on selective thiolyling of NBD (7-nitro-1,2,3-benzoxadiazole) ether were explored for sensing of H2S in aqueous buffer. The syntheses of both probes are simple and quite straightforward. The probes ar...

A highly selective and sensitive near-infrared fluorescent probe for imaging of hydrogen sulphide in living cells and mice

Hydrogen sulphide (H2S), the third endogenous gaseous signalling molecule, has attracted attention in biochemical research. The selective detection of H2S in living systems is essential for studying its functions. Fluorescence detection methods have become useful tools to explore the physiological roles of H2S because of their real-time and non-destructive characteristics. Herein we report a ne...

A cancer cell-specific two-photon fluorescent probe for imaging hydrogen sulfide in living cells

Hydrogen sulfide (H2S) could induce the proliferation of cancer cells in a concentration-dependentmanner, and has close relation with the tumor growth. Monitoring the H2S level in real-time is of great important for understanding its roles in the cancer cell proliferation and the diagnosis of the tumor. Herein, a novel cancer cell-specific two-photon fluorescent probe BN-H2S for detecting H2S i...

A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo.

Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in viv...